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Sub-cytotoxic concentrations of ionic silver promote the proliferation of human keratinocytes by inducing

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《医学前沿（英文）》 2018年第12卷第3期页码 289-300 doi: 10.1007/s11684-017-0550-7

摘要：

Silver-containing preparations are widely used in the management of skin wounds, but the effects of silver ions on skin wound healing remain poorly understood. This study investigated the effects of silver ions (Ag⁺) on the proliferation of human skin keratinocytes (HaCaT) and the production of intracellular reactive oxygen species (ROS). After treating HaCaT cells with Ag⁺and/or the active oxygen scavenger N-acetyl cysteine (NAC), cell proliferation and intracellular ROS generation were assessed using CCK-8 reagent and DCFH-DA fluorescent probe, respectively. In addition, 5-bromo-2-deoxyUridine (BrdU) incorporation assays, cell cycle flow cytometry, and proliferating cell nuclear antigen (PCNA) immunocytochemistry were conducted to further evaluate the effects of sub-cytotoxic Ag⁺ concentrations on HaCaT cells. The proliferation of HaCaT cells was promoted in the presence of 10⁻⁶ and 10⁻⁵ mol/L Ag⁺ at 24, 48, and 72 h. Intracellular ROS generation also significantly increased for 5–60 min after exposure to Ag⁺. The number of BrdU-positive cells and the presence of PCNA in HaCaT cells increased 48 h after the addition of 10⁻⁶ and 10⁻⁵ mol/L Ag⁺, with 10⁻⁵ mol/L Ag⁺ markedly increasing the cell proliferation index. These effects of sub-cytotoxic Ag⁺ concentrations were repressed by 5 mmol/L NAC. Our results suggest that sub-cytotoxic Ag⁺ concentrations promote the proliferation of human keratinocytes and might be associated with a moderate increase in intracellular ROS levels. This study provides important experimental evidence for developing novel silver-based wound agents or dressings with few or no cytotoxicity.

关键词： ionic silver human keratinocyte cell proliferation reactive oxygen species active oxygen scavenger NAC

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Challenges of human–machine collaboration in risky decision-making

《工程管理前沿（英文）》 2022年第9卷第1期页码 89-103 doi: 10.1007/s42524-021-0182-0

摘要： The purpose of this paper is to delineate the research challenges of human–machine collaboration in risky decision-making. Technological advances in machine intelligence have enabled a growing number of applications in human–machine collaborative decision-making. Therefore, it is desirable to achieve superior performance by fully leveraging human and machine capabilities. In risky decision-making, a human decision-maker is vulnerable to cognitive biases when judging the possible outcomes of a risky event, whereas a machine decision-maker cannot handle new and dynamic contexts with incomplete information well. We first summarize features of risky decision-making and possible biases of human decision-makers therein. Then, we argue the necessity and urgency of advancing human–machine collaboration in risky decision-making. Afterward, we review the literature on human–machine collaboration in a general decision context, from the perspectives of human–machine organization, relationship, and collaboration. Lastly, we propose challenges of enhancing human–machine communication and teamwork in risky decision-making, followed by future research avenues.

关键词： human–machine collaboration risky decision-making human–machine team and interaction task allocation human–machine relationship

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Zooming in and out of ferroptosis in human disease

《医学前沿（英文）》 2023年第17卷第2期页码 173-206 doi: 10.1007/s11684-023-0992-z

摘要： Ferroptosis is defined as an iron-dependent regulated form of cell death driven by lipid peroxidation. In the past decade, it has been implicated in the pathogenesis of various diseases that together involve almost every organ of the body, including various cancers, neurodegenerative diseases, cardiovascular diseases, lung diseases, liver diseases, kidney diseases, endocrine metabolic diseases, iron-overload-related diseases, orthopedic diseases and autoimmune diseases. Understanding the underlying molecular mechanisms of ferroptosis and its regulatory pathways could provide additional strategies for the management of these disease conditions. Indeed, there are an expanding number of studies suggesting that ferroptosis serves as a bona-fide target for the prevention and treatment of these diseases in relevant pre-clinical models. In this review, we summarize the progress in the research into ferroptosis and its regulatory mechanisms in human disease, while providing evidence in support of ferroptosis as a target for the treatment of these diseases. We also discuss our perspectives on the future directions in the targeting of ferroptosis in human disease.

关键词： ferroptosis human disease iron metabolism lipid peroxidation antioxidation

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Tackling global electricity shortage through human power: Technical opportunities from direct or indirectutilizations of the pervasive and green human energy

Dan DAI, Jing LIU

《能源前沿（英文）》 2012年第6卷第3期页码 210-226 doi: 10.1007/s11708-012-0200-3

摘要： With the energy and environmental problems becoming increasingly serious, human power, as a pervasive, renewable, mobile and environment friendly energy, draws more and more attention over the world. In this paper, the most basic features of human power are presented. The currently available human power harvesting theories and devices are briefly reviewed and compared. Further, direct or indirect utilization of human power in daily life, especially transportation and home appliances, such as human-powered car, watercraft, aircraft, washing machine and television etc. are summarized. Considering that the total energy from an individual is rather limited, as previously focused by most of the former works, it is conceived in this paper that an important future for large scale use of human powers lies in the efficient conversion, collection and storage of such energy from discrete people and then use it later on as desired. With the huge amount of energy gathered, the application category of human power would be significantly expended. Starting from this point, three technical ways towards efficiently utilizing human power are sketched, which are termed as human-powered grid (HPG), human-powered charger (HPC) and human-powered storage (HPS), among which, HPG is capable of collecting the electric power produced by each individual at different regions and thus can supply unique and flexible power to the customers covered in the area, without relying on the conventional electricity grid. The HPC can then charge various kinds of electrical devices instantly by a human driven generator which converts human power into electricity. Finally, the HPS can store electricity in time for later use. In this way, even for the devices requiring electricity that is strong enough, the collected human power can also serve as its reliable energy source. Meanwhile, utilization of human power becomes rather convenient and timely which guarantees its practical value. It is expected that with further research and increasing applications, human power could partially relieve the current global electricity shortage and environmental issues via its pervasive contribution.

关键词： human energy harvesting human-powered transportation human-powered home appliances human-powered grid (HPG) human-powered charger (HPC) human-powered storage (HPS) biofuel

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Implantation of human umbilical cord mesenchymal stem cells for ischemic stroke: perspectives and challenges

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《医学前沿（英文）》 2015年第9卷第1期页码 20-29 doi: 10.1007/s11684-014-0371-x

摘要：

Ischemic stroke is a focal cerebral insult that often leads to many adverse neurological complications severely affecting the quality of life. The prevalence of stroke is increasing throughout the world, while the efficacy of current pharmacological therapies remains unclear. As a neuroregenerative therapy, the implantation of human umbilical cord mesenchymal stem cells (hUC-MSCs) has shown great possibility to restore function after stroke. This review article provides an update role of hUC-MSCs implantation in the treatment of ischemic stroke. With the unique “immunosuppressive and immunoprivilege” property, hUC-MSCs are advised to be an important candidate for allogeneic cell treatment. Nevertheless, most of the treatments are still at primary stage and not clinically feasible at the current time. Several uncertain problems, such as culture conditions, allograft rejection, and potential tumorigenicity, are the choke points in this cellular therapy. More preclinical researches and clinical studies are needed before hUC-MSCs implantation can be used as a routinely applied clinical therapy.

关键词： cellular therapy transplantation human umbilical cord mesenchymal stem cells ischemic stroke

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Immunological and virological characteristics of human immunodeficiency virus type 1 superinfection:

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《医学前沿（英文）》 2017年第11卷第4期页码 480-489 doi: 10.1007/s11684-017-0594-8

摘要：

Superinfection is frequently detected among individuals infected by human immunodeficiency virus type I (HIV-1). Superinfection occurs at similar frequencies at acute and chronic infection stages but less frequently than primary infection. This observation indicates that the immune responses elicited by natural HIV-1 infection may play a role in curb of superinfection; however, these responses are not sufficiently strong to completely prevent superinfection. Thus, a successful HIV-1 vaccine likely needs to induce more potent and broader immune responses than those elicited by primary infection. On the other hand, potent and broad neutralization responses are more often detected after superinfection than during monoinfection. This suggests that broadly neutralizing antibodies are more likely induced by sequential immunization of multiple different immunogens than with only one form of envelope glycoprotein immunogens. Understanding why the protection from superinfection by immunity induced by primary infection is insufficient and if superinfection can lead to cross-reactive immune responses will be highly informative for HIV-1 vaccine design.

关键词： human immunodeficiency virus type I superinfection incidence immune response

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An experimental analysis of human straight walking

Tao LI, Marco CECCARELLI

《机械工程前沿（英文）》 2013年第8卷第1期页码 95-103 doi: 10.1007/s11465-013-0357-4

摘要：

In this paper, an experimental analysis of human straight walking has been presented. Experiments on human walking were carried out by using Cassino tracking system which is a passive cable-based measuring system. This system is adopted because it is capable of both pose and wrench measurements with fairly simple monitoring of operation. By using experimental results, trajectories of a human limb extremity and its posture have been analyzed; forces that are exerted against cables by the limb of a person under test have been measured by force sensors as well. Furthermore, by using experimental tests, modeling and characterization of the human straight walking gait have been proposed.

关键词： human locomotion walking gait characterization humanoid robot biped robot

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Perfluoroalkane acids in human milk under the global monitoring plan of the Stockholm Convention on Persistent

《环境科学与工程前沿（英文）》 2022年第16卷第10期 doi: 10.1007/s11783-022-1541-8

摘要：

● Perfluorooctanesulfonic acid and perfluorooctanoic acid highest in human milk.

关键词： Human biomonitoring Human breast milk LC-MS/MS analysis Lifestyle parameters

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Glorious Missions Assigned by the Human History

Jian Song

《工程管理前沿（英文）》 2014年第1卷第1期页码 1-1 doi: 10.15302/J-FEM-2014001

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An experimental characterization of human torso motion

Daniele CAFOLLA,I-Ming CHEN,Marco CECCARELLI

《机械工程前沿（英文）》 2015年第10卷第4期页码 311-325 doi: 10.1007/s11465-015-0352-z

摘要：

The torso plays an important role in the human-like operation of humanoids. In this paper, a method is proposed to analyze the behavior of the human torso by using inertial and magnetic sensing tools. Experiments are conducted to characterize the motion performance of the human torso during daily routine operations. Furthermore, the forces acting on the human body during these operations are evaluated to design and validate the performance of a humanoid robot.

关键词： experimental biomechanics human torso analysis inertial sensor characterization

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The size distribution of airborne bacteria and human pathogenic bacteria in a commercial composting plant

《环境科学与工程前沿（英文）》 2021年第15卷第3期 doi: 10.1007/s11783-020-1356-4

摘要：

•Bacterial concentrations from eight stages were 10⁴–10⁵copies/m³.

关键词： Size distribution Airborne bacteria Biological diversity Human pathogenic bacteria Composting plants

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核电人因工程领域的发展

杨孟琢

《中国工程科学》 2002年第4卷第8期页码 12-19

摘要：

核电人因工程是核工程技术的一个组成部分，是研究人机交互作用，把人的特点引入核电工程设计，获得安全和高效的工艺设备与系统的新兴工程技术领域。结合我国走过的道路，重点论述了核电人因工程领域的形成、进展以及发展方向，同时也介绍了作者提出的人的可靠性的综合分类理论和其它研究成果。

关键词：核电人因工程控制室系统人的可靠性综合分类法

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Methodological challenges to human medical study

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《医学前沿（英文）》 2014年第8卷第3期页码 328-336 doi: 10.1007/s11684-014-0359-6

摘要：

With the transformation of modern medicinal pattern, medical studies are confronted with methodological challenges. By analyzing two methodologies existing in the study of physical matter system and information system, the article points out that traditional Chinese medicine (TCM), especially the treatment based on syndrome differentiation, embodies information conception of methodological positions, while western medicine represents matter conception of methodological positions. It proposes a new way of thinking about combination of TCM and western medicine by combinating two kinds of methodological methods.

关键词： medical paradigm traditional Chinese medicine western medicine scientific view scientific methodology

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Hip-mounted electromagnetic generator to harvest energy from human motion

Dan DAI,Jing LIU

《能源前沿（英文）》 2014年第8卷第2期页码 173-181 doi: 10.1007/s11708-014-0301-2

摘要： A type of electromagnetic hip-mounted generator (EHG) is proposed to harvest energy from human hip motion to generate electricity. Based on the law of electromagnetic induction, the EHG generator can convert the kinetic power of the thigh swing into electrical energy during walking or running. To demonstrate the feasibility of the present method, a prototype of the EHG has been designed and fabricated. A theoretical analysis has been conducted to interpret the working behavior of this prototype. In addition, the performance of the system has been experimentally tested through a rotary motor and human body motion. When driven by the rotary motor at a rotation speed of 100 r/min, the open-circuit voltage of this prototype is 2.5 V. Further, a maximum open-circuit voltage of approximately 1 V and a maximum output power of 284 μW could be produced respectively when walking with an EHG at a speed of 1.47 m/s. This handy renewable energy technology is promising as a pervasive electricity generation system for a group of wearable or implanted sensors, actuators and mobile electronics.

关键词： human power harvesting pervasive energy electricity generation wearable energy renewable and sustainable energy mobile electronics

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Wearable thermal energy harvester powered by human foot

Guodong XU, Yang YANG, Yixin ZHOU, Jing LIU

《能源前沿（英文）》 2013年第7卷第1期页码 26-38 doi: 10.1007/s11708-012-0215-9

摘要： With explosive applications of many advanced mobile electronic devices, a pervasive energy system with long term sustainability becomes increasingly important. Among the many efforts ever tried, human power is rather unique due to its independence of weather or geographical conditions and is therefore becoming a research focus. This paper is dedicated to demonstrate the possibility and feasibility of harvesting thermal energy from human body by sandwiching a thermoelectric generator (TEG) between human shoe bottom and ground, aiming to power a portable electronic device. Through the conceptual experiments conducted on adults, a maximum 3.99 mW steady state power output at a ground temperature with 273 K is obtained, which is sufficient enough to drive a lot of micro-electronic devices. Also, parametric simulations are performed to systematically clarify the factors influencing the TEG working performance. To further reveal the mechanism of this power generation modality, analytical solutions to the coupled temperature distributions for human foot and TEG module are obtained and the correlation between TEG characteristics and the output power are studied. It was demonstrated that, the TEG working as a wearable power resource by utilizing thermal energy of human foot shows enormous potential and practical values either under normal or extreme conditions.

关键词： human power thermal energy energy harvesting micro power wearable device

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标题作者时间类型操作

Sub-cytotoxic concentrations of ionic silver promote the proliferation of human keratinocytes by inducing

null

期刊论文

Challenges of human–machine collaboration in risky decision-making

期刊论文

Zooming in and out of ferroptosis in human disease

期刊论文

Tackling global electricity shortage through human power: Technical opportunities from direct or indirectutilizations of the pervasive and green human energy

Dan DAI, Jing LIU

期刊论文

Implantation of human umbilical cord mesenchymal stem cells for ischemic stroke: perspectives and challenges

null

期刊论文

Immunological and virological characteristics of human immunodeficiency virus type 1 superinfection:

null

期刊论文

An experimental analysis of human straight walking

Tao LI, Marco CECCARELLI

期刊论文

Perfluoroalkane acids in human milk under the global monitoring plan of the Stockholm Convention on Persistent